Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3 Expression, Low Phosphocholine, and Kypholordosis

Ranjula Wijayatunge,Sam R. Holmstrom, Samantha B. Foley, Victoria E. Mgbemena,Varsha Bhargava, Gerardo Lopez Perez,Kelly McCrum,Theodora S. Ross

Molecular and Cellular Biology（2018）

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摘要

Deficiency of huntingtin-interacting protein 1 (Hip1) results in degenerative phenotypes. Here we generated a Hip1 deficiency allele where a floxed transcriptional stop cassette and a human HIP1 cDNA were knocked into intron 1 of the mouse Hip1 locus.

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