Prednisolone for the First Rhinovirus-Induced Wheezing and 4-Year Asthma Risk: A Randomized Trial

A Koistinen, M Lukkarinen, R Turunen. Pediatr Allergy Immunol. 2017;28(6):557–563 To investigate the effect of rhinovirus load on the effectiveness of oral corticosteroid (OCS) use on the subsequent development of asthma in children with a history of rhinovirus-induced wheezing. The study population included Finnish children, ages 3 to 23 months, born ≥36 gestational weeks, with a first acute wheezing episode found to be positive for rhinovirus via PCR test of nasopharyngeal aspirate. A total of 59 (75%) children who had sufficient data about rhinovirus load and follow-up were included in the analysis. This was a prospective, randomized placebo-controlled trial in Finland. At study entry, during the first-time acute wheezing episode, children between 3 and 23 months of age …