Preliminary Research on Excretion of Urinary 8-Hydroxyguanosine (8-OHdG) as a Marker of Health Status in Japanese Macaque (<i>Macaca fuscata</i>)

Urinary 8-hydroxyguanosine (8-OHdG), a common biomarker of oxidative stress, was measured in captive Japanese macaques (Macaca fuscata). In asymptomatic and symptomatic macaques, urinary 8-OHdG ranged from 6.9 to 203.2 and from 150.0 to 291.0ng/mg creatinine, respectively. The values for the asymptomatic macaques were significantly lower than those for the symptomatic macaques (P<0.05). Due to the low sample number in the present study, it was not possible to determine the critical value for urinary 8-OHdG in macaques. However, if more data on the variation of urinary 8-OHdG excretion in macaques is obtained, it will be possible to evaluate their general health status based on oxidative stress.