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C3orf21 and Notch Signaling in Cancer：A Potential Biomarker

Zhang Yongjun,Deng Dehou,Bao Wenlong

International Journal of Pathology and Clinical Research（2018）

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Abstract
C3orf21 (chromosome 3 open reading frame 21), also known as xyloside xylosyltransferase 1 (XXYLT1), is located on chromosome 3q29. C3orf21 belongs to the glycosyltransferase 8 family, furthermore, it is a retaining glycosyltransferase. In the extracellular domain of target proteins, XXYLT1 catalyzes addition of the second sylose, and then elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats.
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Key words
notch signaling,cancer：a,biomarker
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