SiO₂-Based Aerogels Modified by Covalently Bonded Aromatic Acids as Potential Drug Delivery Systems

S.A. Lermontov,N.A. Sipyagina,A.N. Malkova,A.E. Baranchikov,V.K. Ivanov,Kh.E. Yorov

Biomedical Chemistry: Research and Methods（2018）

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Abstract

Hybrid aerogels (AGs) containing NH2-group were acylated by benzoic and salicylic acids. The acylated AGs had the specific area value of 170-220m2/g and were not deacylated in H2O-iPrOH mixture at 37°С during 24h. In 0.5% HCl at 37°С hydrolysis takes place releasing free acids and giving the possibility to use aminoaerogels as drug delivery system.

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Key words

aerogels,covalently bonded aromatic acids,drug delivery

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