Impact of curcumin with and without (+/-) piperine on tamoxifen exposure.

Gerardus Hussaarts,Daan Hurkmans,Esther Oomen De Hoop, Leonie J. van Harten, Stan Berghuis,Robbert J. van Alphen, Leontine E.A. Spierings, Quirine C. van Rossum,Mijntje B. Vastbinder, Ron H.N. van Schaik, Teun van Gelder,A. Jager, Roelof W.F. van Leeuwen,Ron H.J. Mathijssen

Journal of Clinical Oncology（2018）

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摘要

2572Background: Tamoxifen is extensively used as endocrine therapy for breast cancer. It is a prodrug that is primarily metabolized by CYP2D6 and CYP3A4, particular into endoxifen. In daily practic...

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tamoxifen exposure,curcumin

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