Yolk sac steps up to the plate

JOURNAL OF EXPERIMENTAL MEDICINE（2022）

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摘要

Atkins et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20211924) create a PSC differentiation model for human yolk sac hematopoiesis and discover multipotent progenitors with erythro-myeloid and T lymphoid potential. The multipotent progenitors emerge via hemogenic endothelium and share origin with primitive erythroid wave in KDR(+)CD235a/b(+) mesoderm.

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