AB036. P007. BM-derived cells differentiated into multilineage hematopoietic cells regulate invasion and proliferation of pancreatic cancer

Background: Pancreatic adenocarcinoma is characterized by a desmoplastic reaction, which provokes treatment resistance. Tumor-stroma interactions promote cancer malignancy. Cytokines secreted by tumor cells differentiate activated macrophages into tumor-associated macrophages (TAMs), which produce angiogenesis factor and cell growth factor to form tumor microenvironment. In breast cancer, a subset of stromal cells was descended from bone marrow (BM)-derived cells. While BM-derived cells seem to be involved in remodeling of microenvironment and tumor progression in pancreatic cancer, this mechanism remains unknown. We aimed to investigate an association between pancreatic cancer progression and BM-derived cells.