Clinical assessment of Citrosept Dental effectiveness in treatment of Candida-associated denture stomatitis, in patients using removable acrylic dentures

Introduction. For patients using removable dentures the level of comfort and thus the life quality has substantially increased with the development of prosthetic dentistry. However, denture stomatitis, especially accompanied by fungal infections, remains a problem and affects many patients using prosthetic restorations. It is mainly caused by an increasing resistance of fungi to antifungal medications. Aim of the study. To assess clinically the effectiveness of a herbal grapefruit seed extract product called Citrosept Dental in treating Candida-associated denture stomatitis, in patients using acrylic removable dentures. Materials and methods. The studied group included 32 patients (18 women and 14 men) of the Department of Prosthetic Dentistry, Medical University of Warsaw, aged 41 to 83 years (average age 62 years), with symptoms of denture stomatitis accompanied by fungal infections, which were confirmed by a mycological test (group 1). Patients with a positive mycological test result used 1% Citrosept Dental gel on mucosal lesions three times a day after meals, for three weeks. Results. The lesions disappeared completely in 24 patients (75%) after three weeks of Citrosept Dental application. The mucosa of 13 patients with type 1 stomatitis (81.25%) was pink and healthy; that was also the case of 78.57% patients with diffuse erythema. In the three remaining patients with type 2 stomatitis lesions healed after using Citrosept Dental and only had single pinpoints of hyperaemia. There was no change in the oral mucosa of the patient with type 3 stomatitis. Conclusions. Citrosept Dental in in vivo studies reduced denture-associated mucosal inflammations in patients with denture stomatitis accompanied by fungal infections, and also produced resolution of subjective symptoms in a significant majority of patients.