Scientific and Methodological Support of Activities on Carrying Out Immunological Monitoring of Vaccinated Against Plague Persons Residing in the Territories of Natural Foci of the Infection

The article covers the issues related to the scientific substantiation and methodological support of immunological monitoring of persons vaccinated against plague upon epidemic indications. The problematic issues of the methodology for the assessment of immunological efficiency (efficacy) of plague live vaccine (PLV) are noted. The current tasks and possible prospects for the introduction of immunological monitoring of persons vaccinated against plague upon epidemic indications have been defined. The algorithm of efficacy estimation of plague live vaccine in vaccinated (revaccinated) persons has been tested under real conditions. Analysis of the results of efficacy evaluation of plague live vaccine among vaccinated (revaccinated) people against plague living in the territories of natural foci of this infection has been performed. Demonstrated is the possibility of using immunological monitoring results in creating an objective basis for improving the strategy of specific plague prevention in natural foci of this infection. The priority areas for further optimization of the specific plague prevention in the territories of natural foci of the infection, including those related to the formation of individual regimen revaccination tactics, taking into account the possibilities of creating modern and effective vaccines, are outlined.