Explainable Artificial Intelligence for Magnetic Resonance Imaging Aging Brainprints: Grounds and challenges

Marked changes occur in the brain during people’s lives, and individual rates of aging have revealed pronounced differences, giving rise to subject-specific brainprints that are the signature of the brain. These are shaped by a great variety of factors, both endogenous and exogenous. Accurate predictions of brain age (BA) can be derived from neuroimaging endophenotypes by using machine and deep le...