Phyre and PhyreRisk – Integrating genetic variant data with experimental and predicted protein structures and their complexes

Lawrence A Kelley,Alessia David,Sirawit Ittisoponpisan,Stefans Mezulis,Tochukwu C Ofoegbu,Devlina Chakravarty,Petras J Kundrotas,Ilya A Vakser,Michael Sternberg

EasyChair Preprints（2018）

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摘要

Phyre is a widely-used web server for tertiary protein structure prediction and modelling with over 80,000 distinct users per year and is part of the ELIXIR tools resource. We are developing 3D models for predicted complexes by integrating tertiary models, the experimental structure of complexes and protein-protein interaction data. A new resource, PhyreRisk, is being developed which will enable users to map protein missense variants onto experimental and predicted tertiary structures and complexes. See www.sbg.bio.ic.ac.uk/~phyre2 and phyrerisk.bc.ic.ac.uk

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