Mutation profiling in tumor samples using the Sequenom OncoCarta ™ Panel

Sequenom's MassARRAY ® system enables sensitive and rapid somatic mutation profiling in solid tumors or cell lines. Our validation studies revealed mutations in most of the oncogenes analyzed, and the mutation frequency was consistent with previous reports. We also found new low-frequency mutations in our tumor samples, indicating that rare and potentially targetable mutations can be identified with this approach.