Trials of interventions for people with psychosis

Schizophrenia is a severe mental disorder that causes serious and persistent disability in multiple domains. People with schizophrenia are also often exposed to widespread sigma, discrimination, and human rights abuse. There is a large and persistent treatment gap for people with schizophrenia and their caregivers globally and in LAMIC;To address this gap, emerging observational evidence from LAMIC suggests that a task-sharing strategy involving community health workers (CHWs) is a feasible option for delivering services to people with schizophrenia and their families . However, there is no RCT evidence from LAMIC that such an approach is more effective than usually available care. The community care for people with schizophrenia in India (COPSI) RCT tested the clinical and cost-effectiveness of a collaborative community-based care (CCBC) intervention with usual, facility-based care (FBC). The FBC + CCBC intervention was superior in reducing symptoms and disability associated with schizophrenia and in improving adherence with treatment.