Hyper-Homocysteinemia and other Inherited Thrombophilic Factors Inducing Retinal Vein Occlusion. The Employment of Novel Orals Anti-Coagulants is Possible?

Retinal Vein Occlusion (RVO) is the second cause of unilateral visual loss, and can have ischemic or non-ischemic aetiology. The causes inducing RVO may be due to thrombophilia induced by acquired or inherited risk factors. We refer on inherited thrombophilic factors alone, such as Hyper-Homocysteinemia (HHcy) (due to Methylene-Tetra-Hydro-Folate Reductase (MTHFR) gene mutation), primary antiphospholipid syndrome, factor V Leiden mutation, protein C, protein S and antithrombin deficiencies, and prothrombin mutation. Medical treatment for RVO prevention, has been based on traditional anticoagulant drugs (heparins and oral vitamin K antagonists).