Synthesis and structure–activity relationship of N⁴-benzylamine-N²-isopropyl-quinazoline-2,4-diamines derivatives as potential antibacterial agents

Zhengyun Jiang,W. David Hong,Xiping Cui,Hongcan Gao,Panpan Wu,Yingshan Chen,Ding Shen,Yang Yang,Bingjie Zhang,Mark J. Taylor,Stephen A. Ward,Paul M. O'Neill,Suqing Zhao,Kun Zhang

RSC Advances（2017）

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摘要

This paper investigated the SAR of the N4-benzylamine-N2-isopropyl-quinazoline-2,4-diamines derivatives with heterocyclic scaffold which showed good activities against S. aureus, E. coli, MRSA, S. epidermidis and S. typhimurium.

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Synthesis and structure–activity relationship of N4-benzylamine-N2-isopropyl-quinazoline-2,4-diamines derivatives as potential antibacterial agents

Synthesis and structure–activity relationship of N⁴-benzylamine-N²-isopropyl-quinazoline-2,4-diamines derivatives as potential antibacterial agents