Clinical implementation of genome editing for correction of human diseases

Genome editing is a breakthrough technology which consists of the process of precise modifications introduction into the genome of any organism.This scientific breakthrough provides a powerful tool for the errors correction in the nucleotide sequence of DNA.The development of the genome editing has inverted the concept of an available target for the therapeutic correction.The opportunity of highly precise and safe entering of single-and double-stranded breaks into the human DNA followed by natural DNA repair mechanisms has changed current approaches of the gene therapy and opened up new horizons in the treatment of numerous diseases.Genome editing is being developed to treat not only monogenic diseases but also infectious diseases and cancer.In the current review, we discuss the therapeutic application of genome editing.