Crucial role of innate immune system in the pathogenesis of celiac disease

Celiac disease (CD) is a chronic autoimmune disorder caused by ingestion of gluten peptides in genetically predisposed individuals. In susceptible individuals, immune response to gluten results in intestinal damage and a wide range of clinical manifestations. Although both of innate and adaptive immunity is importance for response to gluten but innate system play a critical role in initiation of this process. Thus the main objective of this review is to investigate the role of innate immune system in the pathogenesis of celiac disease.