Beneficial Effects of Vitamin D Treatment in an Obese Mouse Model of Non-Alcoholic Steatohepatitis

25-OH vitamin D3 (VD3) serum levels negatively correlate with obesity and furthermore with the development and progression of non-alcoholic fatty liver disease (NAFLD) in humans. However, the mechanisms linking low VD3 status to disease progression are not completely understood. In this study, we analysed whether VD3 treatment ameliorates non-alcoholic steatohepatitis (NASH) in a mouse model of diet-induced obesity and how this amelioration may be associated with changes of intestinal physiology.