After Long Term Electroconvulsive Therapy, Gliosarcoma with Primitive Neuroectodermal Tumor-like Components: A Case Report

We present a rare case of gliosarcoma (GS) with primitive neuroectodermal tumor (PNET)-like components. A 63-year-old female patient with right-sided weakness for the last five months. In her medical history, she has schizophrenia and has antipsychotic treatment and electroconvulsive therapy (ECT) for 30 years. In her cranial MRI, there is a 56x50x46 mm cystic mass lesion with superior nodular solid components at the posterior of the central sulcus of the left parietal lobe. By examining the histomorphological and immunohistochemical findings of the cranial surgery material, the case was found consistent with GS with PNET-like components according to the WHO 2007 grade. When assessing the causes of GS, there are some aspects restricting to study of GS with PNET-like components because GS is a rare tumor and GS with PNETlike components is very rare tumor. There were reported that primary and secondary GS cases have been associated with postradiation therapy. However, as in our case, there has not been found an evidence that long term ECT causes GS. It is thought that if long term ECT causes GS.