Ps 02-43 procollagen type i carboxy-terminal propeptide is associated with blood pressure, cardiac hypertrophy and dysfunction, and predict cardiovascular events in hemodialysis patients

Objective: Serum procollagen type I carboxy-terminal propeptide (PICP) is a marker of myocardial fibrosis in hypertensive heart disease. However, the clinical significance of PICP is less determined in end-stage renal disease (ESRD) patients. This study was to evaluate the association of predialysis serum PICP levels with blood pressure (BP), cardiac hypertrophy and function, and cardiovascular (CV) events in hemodialysis patients. Design and Method: Serum PICP and other parameters were obtained from predialysis blood samples of 123 incidental hemodialysis patients. The patients were divided into a low PICP group (n = 61) and high PICP group (n = 62). Baseline laboratory parameters, BP pressure, echocardiographic parameters including left ventricular mass index (LVMI) and ejection fraction, ratio of peak early transmitral flow velocity to peak early diastolic mitral annular velocity (E/E’ ratio), ratio of peak early transmitral flow velocity to peak late transmitral flow velocity (E/A ratio), and mitral valve-deceleration time (DT) were compared between groups. The associations between serum PICP and mortality and cardiovascular (CV) events were also investigated. Results: Serum PICP was obtained from predialysis blood samples of 123 incidental hemodialysis patients. The patients were divided into a low PICP group (n = 61) and high PICP group (n = 62). Baseline laboratory parameters, BP pressure, echocardiographic parameters were compared between groups. The associations between serum PICP and mortality and cardiovascular (CV) events were also investigated. Conclusions: Serum PICP is significantly associated with left ventricular hypertrophy and dysfunction, and predicts CV events in incidental hemodialysis patient.