ГОСТРА ТОКСИЧНІСТЬ ГЛІФОСАТУ ДЛЯ ПЕРЕПЕЛІВ

The article deals with the data on the establishment of acute toxicity herbicide glyphosate for quail for oral administration. Glyphosate - the herbicide with broad spectrum of activity. In experiments it was used glyphosate in the form of potassium salt preparation with the concentration of 676 g/dm3. The experiments were carried out on 91 female of Texas quail breeds the average weight is (200.0 ± 20.0) g, and were kept under optimal conditions of vivarium. According to the principle of analogues were formed 4 experimental groups, which were administered glyphosate in the form of an aqueous emulsion in doses - 50, 500, 2000, and 5000 mg/kg of body weight. For clinical state of the research poultry it was observed for 14 days. It was noted the emergence and the development of clinical signs of poisoning, term loss or recovery period to physiological norm. A single intragastric administration of water glyphosate emulsion to quail of I - III research groups caused no picture of acute poisoning. In the poultry from the experimental group during the first six hours of the experiment it was recorded gradual growth inhibition. For acute poisoning in quail it was showed depression, poor response to external stimuli, sitting in one place. Poultry death was observed in this group during the first day after the introduction of glyphosate. On pathoanatomical autopsy it was established that the absence of the oral cavity mucous membranes changes, pharynx trachea and esophagus; increased liver, filled with blood, dark cherry colour, gallbladder filled with bile, blood supply vessels of the small intestine, it was observed swelling of the blind shoots the colon; kidneys increased in volume compared to the control group swelling of the large bowel; kidneys increased in volume compared to the control group. According to the results of the quail death DL50 was calculated, which was 5039.11 ± 222.96 mg/kg, which gives reason to include glyphosate according hygienic classification of pesticides for L.I. Medvedj and DSP 8.8.1.2.002-98 to little toxic substances to (4th class of danger).