N400 potential generators in response to visually presented images are spread across both cerebral hemispheres.

Event Abstract Back to Event N400 potential generators in response to visually presented images are spread across both cerebral hemispheres. Elvira Khachatryan1*, Nikolay Chumerin1, Evelien Carrette2, Flavio Camarrone1, Leen De Taeye3, Alfred Meurs2, Paul Boon3, Dirk Van Roost2 and Marc M. Van Hulle1 1 KU Leuven, Neurophysiology, Belgium 2 Ghent University Hospital, Belgium 3 Ghent University, Belgium N400 is a negative EEG potential evoked by a meaningful stimulus. It is usually modulated by semantic relatedness of consecutive linguistic and non-linguistic stimuli such as images. Recent research showed that neuronal generators of N400 in response to these two types of stimuli differ. By using electrocorticography (ECoG) recordings, we show direct evidence about the localization of the N400 generator in response to semantically-related image pairs. Methods: A semantic image association task was conducted on a patient with refractory epilepsy with depth and subdural grid electrodes implanted in/above the following areas: left (8 electrodes) and right (8 electrodes) hippocampus, right posterior (4 electrodes) and anterior (4 electrodes) temporo-basal neocortex, left temporal neocortex (4×8 grid) and right temporo-lateral neocortex (8 electrodes). Simultaneously with ECoG, EEG was recorded from 27 scalp electrodes (10 – 20 system). Both EEG and ECoG signals were referenced to a common average reference but for the ECoG case, this was done per grid. All signals were filtered between 1 and 15Hz. Trials were corrected using a 100ms pre-stimulus baseline. Results: Student’s t-test showed for ECoG a difference between N400 amplitudes in response to semantically related and unrelated images in the following areas: left hippocampal area (t(1,417)=2.04, p<0.05), right hippocampal area (t(1,417)=4.1, p<0.0001), right posterior (t(1,417)=3.75, p<0.0005) and anterior (t(1,417)=2.8, p=0.005) temporo-basal neocortex and left temporal neocortex (t(1,417)=3.26, p=0.001). The EEG signal showed a clear centro-parietal N400 effect of semantic relatedness. Conclusion: N400 generators for image processing are spread across both hemispheres, unlike the ones for linguistic stimuli, which according to some localization studies, are more confined in the left temporal neocortex. Acknowledgements The work is supported by the Interuniversity Attraction Poles Programme—Belgian Science Policy (IUAP P7/11), research grants received from the Belgian Fund for Scientific Research (FWO) – Flanders (G088314N, G0A0914N), Financing program (PFV/10/008) of the KU Leuven. References Gallagher, A., Béland, R., Vannasing, P., Bringas, M. L., Sosa, P. V., Trujillo-barreto, N. J., … Lassonde, M. (2014). Dissociation of the N400 component between linguistic and non-linguistic processing : A source analysis study. World Journal of Neuroscience, 4(February), 25–39. doi:10.4236/wjns.2014.41004 Kovalenko, L. Y., Chaumon, M., & Busch, N. a. (2012). A pool of pairs of related objects (POPORO) for investigating visual semantic integration: Behavioral and electrophysiological validation. Brain Topography, 25, 272–284. doi:10.1007/s10548-011-0216-8 Kutas, M., & Federmeier, K. D. (2011). Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). Annual Review of Psychology, 62, 621–47. doi:10.1146/annurev.psych.093008.131123 Keywords: electrocorticography, event related potentials (ERP), N400, semantic priming, image processing Conference: Second Belgian Neuroinformatics Congress, Leuven, Belgium, 4 Dec - 4 Dec, 2015. Presentation Type: Poster Presentation Topic: Brain Imaging Citation: Khachatryan E, Chumerin N, Carrette E, Camarrone F, De Taeye L, Meurs A, Boon P, Van Roost D and Van Hulle MM (2015). N400 potential generators in response to visually presented images are spread across both cerebral hemispheres.. Front. Neuroinform. Conference Abstract: Second Belgian Neuroinformatics Congress. doi: 10.3389/conf.fninf.2015.19.00009 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 14 Nov 2015; Published Online: 17 Nov 2015. * Correspondence: Miss. Elvira Khachatryan, KU Leuven, Neurophysiology, Leuven, 3000, Belgium, elvira.khachatryan@med.kuleuven.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Elvira Khachatryan Nikolay Chumerin Evelien Carrette Flavio Camarrone Leen De Taeye Alfred Meurs Paul Boon Dirk Van Roost Marc M Van Hulle Google Elvira Khachatryan Nikolay Chumerin Evelien Carrette Flavio Camarrone Leen De Taeye Alfred Meurs Paul Boon Dirk Van Roost Marc M Van Hulle Google Scholar Elvira Khachatryan Nikolay Chumerin Evelien Carrette Flavio Camarrone Leen De Taeye Alfred Meurs Paul Boon Dirk Van Roost Marc M Van Hulle PubMed Elvira Khachatryan Nikolay Chumerin Evelien Carrette Flavio Camarrone Leen De Taeye Alfred Meurs Paul Boon Dirk Van Roost Marc M Van Hulle Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.