Donepezil plasma concentrations, CYP2D6 and CYP3A4 phenotypes, and cognitive outcome in Alzheimer’s disease

A Coin,M V Pamio,C Alexopoulos,S Granziera,F Groppa,G de Rosa,A. Girardi,G. Sergi,E. Manzato,R Padrini

European Journal of Clinical Pharmacology（2016）

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摘要

Purpose The purpose of the study is to evaluate whether donepezil (D) plasma concentrations and activity of CYP2D6 and CYP3A4 are associated with the therapeutic response of patients with mild to moderate Alzheimer’s disease (AD).

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关键词

cyp3a4 phenotypes,cyp2d6,alzheimers,donepezil plasma concentrations,cognitive outcome

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