Effect of Microencapsulated Hepatocytes Transplantation on Copper Metabolism of Rat Model with Hepatolenticular Degeneration

Objective: To observe the effect of microencapsulated hepatocytes after intraperitoneal transplantation of hepatolenticular degeneration (HDL) of model rats’ serum copper and copper metabolism in liver. Methods: Rat HLD model was made by copper load diet. To prepare microencapsulated hepatocytes by the airflow method, and the method of intraperitoneal transplantation were used with naked cells or the microencapsulated cell transplantation, respectively, compared with blank control group group I), model group(group II), Bare hepatocytes after intraperitoneal transplantation group (group III) and microencapsulated hepatocyte transplantation group(group IV). Determination of HLD rat model of ALT, AST, albumin levels, copper of liver tissue, copper level in serum. Results: II, III, IV groups of rats at each time point of ALT, AST, serum copper, liver copper values were significantly higher than group I rats increased (each P < 0.05), synthesis of albumin levels decreased significantly (each P < 0.05).