Intracellular Signaling

John W. Thompson, Jinchong Xu, Valina L. Dawson, Miguel A. Perez-Pinzon, Ted M. Dawson

Stroke（2022）

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Abstract

In this chapter, we review preconditioning, which is an adaptive response to a noxious but nonlethal experience that activates an intracellular reaction rendering the tissue tolerant to a subsequent potentially lethal event. Harnessing the power of preconditioning and tolerance has promise as a new arena to develop novel therapies to protect the nervous system from ischemic injury.

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