Metformin Modulates Inflammatory Response through AMPK-NF-?B Signaling and Restores Atherogenic Effects

Event Abstract Back to Event Metformin Modulates Inflammatory Response through AMPK-NF-κB Signaling and Restores Atherogenic Effects Bobae Hyun1, Seulmee Shin1, Aeri Lee1, Sungwon Lee1, Youngcheon Song1, Kyunghae Cho2 and Kyungjae Kim1* 1 Sahmyook University, Republic of Korea 2 Seoul Women's University, Republic of Korea Metformin is one of the most widely prescribed drugs for the treatment of type II diabetes. Metformin has been reported to mediate inflammatory responses and attenuate development of atherosclerosis besides its antihyperglycemic effect. But the pharmacological and biochemical mechanisms of metformin in immune responses and atherogenesis have not been clearly elucidated. Here we demonstrate that metformin down-regulates pro-inflammatory cytokines and foam cell formation in macrophages. Metformin reduced the production of NO through the suppressed gene and protein expression of iNOS in LPS-stimulated RAW 264.7 cells and peritoneal macrophages. Metformin antagonized the production of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6, leading to suppressed the phosphorylation of IκBα and the translocation of NF-κB p65 subunit into nuclear. Furthermore, scavenger receptors (SR-A, Lox-1) mRNA levels were down-regulated by metformin. These results show that metformin attenuates inflammatory mediators via AMPK-NF-κB signaling, suggesting that metformin would be a potential immunemodulatory agent for treating vascular inflammatory diseases. Keywords: Metformin, Inflammation, scavenger receptors, NF-κB, AMPK Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Hyun B, Shin S, Lee A, Lee S, Song Y, Cho K and Kim K (2013). Metformin Modulates Inflammatory Response through AMPK-NF-κB Signaling and Restores Atherogenic Effects. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00183 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Prof. Kyungjae Kim, Sahmyook University, Seoul, Republic of Korea, kimkj@syu.ac.kr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Bobae Hyun Seulmee Shin Aeri Lee Sungwon Lee Youngcheon Song Kyunghae Cho Kyungjae Kim Google Bobae Hyun Seulmee Shin Aeri Lee Sungwon Lee Youngcheon Song Kyunghae Cho Kyungjae Kim Google Scholar Bobae Hyun Seulmee Shin Aeri Lee Sungwon Lee Youngcheon Song Kyunghae Cho Kyungjae Kim PubMed Bobae Hyun Seulmee Shin Aeri Lee Sungwon Lee Youngcheon Song Kyunghae Cho Kyungjae Kim Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.