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Association Between the PTPN2 Gene and Crohnʼs Disease

Valerie Marcil,David R. Mack,Vijay Kumar,Christophe Faure,Christopher S. Carlson,Patrick Beaulieu,David Israel,Alfreda Krupoves,Irina Costea,Philippe Lambrette,Guy Grimard,Jinsong Dong,Ernest G. Seidman,Devendra K. Amre,Emile Levy

Inflammatory Bowel Diseases（2013）

Cited 17|Views0
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Abstract
BackgroundAlthough genome-wide association studies (GWAS) and subsequent meta-analyses have confirmed associations between the PTPN2 (protein tyrosine phosphatase, nonreceptor type 2) gene and Crohn's disease (CD), the potential causal variants remain unidentified. We aimed to dissect potential causal CD-associated PTPN2 variants, assess their functional significance, and relate PTPN2 protein expression with inflammation in CD.
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Key words
ptpn2 gene,crohnʼs disease
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