Indonesian Medicinal Plants. III. On the Constituents of the Bark of Fagara rhetza(Rutaceae). (1). Alkaloids, Phenylpropanoids, and Acid Amide.

Two new phenylpropanoids, named O-geranylsinapyl alcohol (1) and O-geranylconiferyl alcohol (2), and a new acid amide, named hazaleamide (3), were isolated from the bark of Fagara vhetza (Rutaceae), an Indonesian medicinal plant from Flores Island, Indonesia. The chemical structures of 1, 2, and 3 have been plucidated on the basis of their chemical and physicochemical properties. Among the three new compounds, hazaleamide (3) was found to show a pungent taste and to exert a moderate antimalarial activity in a in vitro test system.