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Neuroprotective Kaurane Diterpenes fromFritillaria ebeiensis

Jing XU,Ping GUO,Cuizhou LIU,Zhanping SUN,Liping GUI,Yuanqiang GUO,Tohru YAMAKUNI,Yasushi OHIZUMI

Bioscience, Biotechnology, and Biochemistry（2011）

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Abstract
The new kaurane diterpene, ent-3β-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP+-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.
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neuroprotective kaurane diterpenes
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