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Piperidine-derived γ-secretase modulators

Adrian Hall,Richard L. Elliott,Gerard M.P. Giblin,Ishrut Hussain,James Musgrave,Alan Naylor,Rosemary Sasse,Beverley Smith

Bioorganic & Medicinal Chemistry Letters（2010）

Cited 55|Views5
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Abstract
Compound 10h was found to be a potent modulator in vitro and was found to decrease Aβ42, increase Aβ38 and have no effect on Aβ40 levels. Furthermore, 10h demonstrated excellent pharmacokinetic parameters in the mouse, rat and dog in addition to good CNS penetration in the mouse.
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