A Study of the Effect of Aging on Insulin and Glueagon Release during Intravenous Glucose Tolerance Test

Glucose intolerance in elderly had been reported by many investigators. In this study intravenous glucose tolerance test is done for 63 subjects classified into three groups; A (aged 20–40 years), B (aged 40–60 years) and C (aged above 60 years). Signifikant elevation of plasma glucose and insulin with progress of age, and reduction of glucose assimilation as well as insulin stimulating activity and insulin index were observed. No significant differences in plasma glucagon levels or glucagon suppression areas were found among the groups of study; this suggests that glucagon plays no role in reduction of glucose tolerance with aging.