Linkage Analysis of Affective Disorder Using DNA Markers on Chromosomes 11 and X

Shinichiro Nanko, Masaru Kobayashi, Shinobu Gamou,Jun Kudoh,Nobuyoshi Shimizu,Noboru Takazawa, Hajime Kazamatsuri, Toshiyuki Furusho

Psychiatry and Clinical Neurosciences（1991）

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摘要

: We have investigated two pedigrees in an attempt to detect the putative linkages between affective disorder and c-Ha-ras-1 oncogene and the insulin gene on chromosome 11, or hypoxanthhte phosphoribosyltransferase (HPRT) on X chromosome. The linkage between affective disorders and the markers on chromosomes 11 and X was ruled out with the assumption of no recombination.

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