Rapid and Selective Synthesis of Substituted 1,2,5-Thiadiazolidine 1,1-Dioxides.

The reaction of N,N-dimethylsulfamoyl aziridines with primary amines gives direct access to substituted 1,2,5-thiadiazolidines in a regioselective manner. Furthermore, the product from reaction with 4-methoxybenzyl amine can be subsequently manipulated to give the alternative nitrogen substitution pattern in a controlled fashion.