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3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: A Potent and Highly Selective Inducible Nitric Oxide Synthase Inhibitor.

Sofya Tsymbalov,Timothy J. Hagen,William M. Moore,Gina M. Jerome,Jane R. Connor,Pamela T. Manning,Barnett S. Pitzele,E. Ann Hallinan

ChemInform（2003）

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Abstract
(3S,4S,5R)-2-Imino-4-methyl-5-pentyl-3-pyrrolidinol hydrochloride (1) is a potent inducible nitric oxide synthase (i-NOS) inhibitor that has three times the selectivity of its parent, (+)-cis-4-methyl-5-pentylpyrrolidin-2-imine hydrochloride (2).
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Key words
inducible nitric oxide synthase,inhibitor
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