3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic Acids Are Novel Inhibitors of MMP-13 and Aggrecanase.

Mark C. Noe, Sheri L. Snow,Lilli A. Wolf-Gouveia,Peter G. Mitchell,Lori Lopresti-Morrow,Lisa M. Reeves,Sue A. Yocum,Jennifer L. Liras,Marcie Vaughn

ChemInform（2004）

引用 0|浏览0

暂无评分

摘要

N-Hydroxy-3-hydroxy-4-arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase based on known endocyclic hydroxamate inhibitors of matrix metalloproteinases. These compounds offer favorable physicochemical properties and low metabolic clearance. Synthesis and structure-activity relationships are reported.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要