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In vitro permeation of β-lactam antibiotics across rat jejunum and its correlation with oral bioavailability in humans

Hiroshi Saitoh,Bruce J. Aungst,Masashi Tohyama,Yuko Hatakeyama, Keiko Ohwada,Michiya Kobayashi,Hiroko Fujisaki,Katsumi Miyazaki

British Journal of Clinical Pharmacology（2002）

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Abstract
Aims To investigate the correlation between in vitro permeation of 11 β-lactam antibiotics across rat jejunum and their oral bioavailability in humans.
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Key words
oral bioavailability,antibiotics,rat jejunum
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