HOTTIP-dependent R-loop Formation Regulates CTCF Boundary Activity and TAD Integrity in Leukemia

Huacheng Luo,Ganqian Zhu,Melanie A. Eshelman,Tsz Kan Fung,Qian Lai, Fei Wang,Bernd B. Zeisig,Julia Lesperance,Xiaoyan Ma,Shi Chen,Nicholas Cesari,Christopher Cogle,Baoan Chen,Bing Xu,Feng-Chun Yang,Chi Wai Eric So,Yi Qiu,Mingjiang Xu,Suming Huang

Molecular Cell（2022）

引用 51|浏览49

关键词

HOTTIP lncRNA,R-loops,CTCF chromatin boundary,cohesin complex,TAD formation,enhancer/promoter interactions,canonical Wnt transcription,AML leukemogenesis

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