Vitamin B12 enhances the antitumor activity of 1,25-dihydroxyvitamin D3 via activation of caspases and targeting actin cytoskeleton.

Manar F Atoum,Foad E Alzoughool,Zainab A Al-Mazaydeh,Majdoleen S Rammaha,Lubna H Tahtamouni

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine（2022）

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摘要

1,25(OH)2D3 and vitamin B12 exhibited synergistic anticancer effects against different cancer cell lines. The combination therapy of 1,25(OH)2D3 and vitamin B12 may provide a potential adjunctive treatment option for some cancer types.

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关键词

1α,25-Dihydroxyvitamin D3,ER stress,cobalamin,combined therapy,synergistic effects

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