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Inhaled heparin polysaccharide nanodecoy against SARS-CoV-2 and variants

Bin Tu,Huiyuan Wang,Xinran An,Jingkun Qu, Qianqian Li,Yanrong Gao,Mingjie Shi,Hong Qiu,Yongzhuo Huang

Acta Pharmaceutica Sinica B（2022）

Cited 6|Views10
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Abstract
The heparin polysaccharide nanoparticles block the interaction between heparan sulfate/S protein and inhibit the infection of both wild-type SARS-CoV-2 pseudovirus and the mutated strains through pulmonary delivery.Image 1
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Key words
SARS-CoV-2,Delta variant,Heparan sulfate,Spike protein,Heparin nanoparticle,Pulmonary delivery
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