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Novel anti-cytoplasmic antibodies in cerebrospinal fluid and serum of patients with chronic severe mental disorders.

Dominique Endres,Benjamin Pankratz, Sarah Thiem,Kimon Runge,Andrea Schlump,Bernd Feige,Kathrin Nickel,Marco Reisert,Hansjörg Mast,Horst Urbach,Miriam A Schiele,Katharina Domschke,Benjamin Berger,Nils Venhoff,Harald Prüss,Ludger Tebartz van Elst

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry（2022）

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Abstract
The detection of autoantibodies in CSF of chronic SMD may be beneficial in selecting some patients for immunotherapy. The possible impact of novel anti-cytoplasmic antibodies in this context is critically discussed. Further research is needed to establish the underlying pathophysiological processes as well as their diagnostic and therapeutic implications.
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Key words
Autoimmune encephalitis,anti-cytoplasmic antibodies,autoimmune OCD,autoimmune psychosis,cerebrospinal fluid
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