Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation

•Sirt6 regulates Caveolin-1 acetylation and autophagic degradation and subsequently attenuates LDL transcytosis across ECs, ultimately delaying the development of atherosclerosis.•Targeted overexpression or supplement of Sirt6 might become a potential therapeutic strategy for diabetes and its cardiovascular complications.