Inhibition of TRPA1 Attenuates Oxidative Stress-induced Damage After Traumatic Brain Injury via the ERK/AKT Signaling Pathway
Neuroscience(2022)
Abstract
•Traumatic brain injury features Ca2+/reactive oxidative species-related apoptosis.•Traumatic brain injury was modeled in vitro and in vivo.•Traumatic brain injury upregulated TRPA1 expression via Nrf2.•TRPA1 inhibition reduced apoptosis partly via CaMKII/AKT/ERK signaling.•Blockade of TRPA1 might be developed as a treatment for traumatic brain injury.
MoreTranslated text
Key words
AKT,CaMKII,ERK,Nrf2,ROS,TBI,TRPA1
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined