Saireito (TJ-114) Suppressed Donor-Specific Antibody Through Immunomodulatory Effects and Regulatory T Cell Induction in a Murine Heart Transplant Model

Yasuto Yamamoto,Masateru Uchiyama,Kento Kawai,Kazuhito Iguchi,Tomohiro Imazuru,Tomoki Shimokawa

Transplantation Proceedings（2022）

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摘要

•We investigated the effects of TJ-114 on the suppression of donor-specific antibodies.•TJ114 upregulated regulatory T cells and suppressed donor-specific antibody production.•TJ-114 modulated donor-specific antibodies by the promotion of regulatory T cells and other immunomodulatory mechanisms.

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