Link between structural connectivity of the medial forebrain bundle, functional connectivity of the ventral tegmental area, and anhedonia in unipolar depression
NeuroImage: Clinical(2022)
摘要
•Tract volume and number of tracts are reduced in the left slMFB.•Those microstructural alterations are related to depression severity and anhedonia.•There is increased VTA-PFC functional connectivity in depression.•Those increases are more pronounced in patients with severe anhedonia.•Our results extend pathophysiological models of anhedonia in depression.
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关键词
Anhedonia,Depression,Diffusion tensor imaging,Functional MRI,Medial forebrain bundle,Reward system
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