Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson's disease: (Trends in Endocrinology & Metabolism 33, 147-157; 2022).

Due to an error during the proofreading process, Figures 2 and 3 were switched in the manuscript, and as a result, the captions and citations in text referring to the figures do not match up. We apologize for any inconvenience caused to readers. Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson’s diseaseAnis et al.Trends in Endocrinology & MetabolismDecember 21, 2021In BriefTwo hallmarks of Parkinson’s disease (PD) are the widespread deposition of misfolded alpha-synuclein (αSyn) protein in the nervous system and loss of substantia nigra dopamine neurons. Recent research has suggested that αSyn aggregates in the enteric nervous system (ENS) lead to prodromal gastrointestinal (GI) symptoms such as constipation in PD, then propagating to the brain stem and eventually triggering neurodegeneration and motor symptoms. Additionally, whether the microbiome changes in PD contribute to the primary pathogenesis or, alternatively, are consequential to either the disease process or medication is still unclear. Full-Text PDF