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5-Aminolevulinic Acid-Guided Resection in Grade III Tumors-A Comparative Cohort Study.

Asfand Baig Mirza,Jose Pedro Lavrador,Ioannis Christodoulides,Timothy Martyn Boardman,Amisha Vastani,Qusai Al Banna,Razna Ahmed,Irena C F Norman,Christopher Murphy,Sharmila Devi,Anastasios Giamouriadis,Francesco Vergani,Richard Gullan,Ranjeev Bhangoo,Keyoumars Ashkan

Operative neurosurgery (Hagerstown, Md.)（2022）

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Abstract
Despite the benefits of 5-ALA in grade IV glioma surgery, these benefits are limited to a smaller group of patients with grade III tumors where there is sufficient fluorescence to allow GTR. In this cohort of patients, 5-ALA use may result in worse neurological outcomes particularly when GTR is not feasible and therefore caution is warranted.
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5-Aminolevulinic acid,Grade III glioma,Fluorescence-guided surgery,Anaplastic astrocytoma,Resection
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