Exclusive modifications of NuMA in malignant epithelial cells: A potential therapeutic mechanism

Drug Discovery Today（2022）

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摘要

•A cell-death mechanism is evoked by inserting structural faults in the mitotic spindle.•Blocking the post-translational modification of NuMA arrests mitosis.•The PARP inhibitor PJ34 evokes cell-death in cancer cells while targeting NuMA.•The notion that PARP1 inhibition halts cancer by preventing DNA repair is challenged.

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关键词

Human malignant epithelial cells,NuMA,Mitotic spindle,Mitotic catastrophe cell death,PJ34,PARP1 inhibitors

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