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LncRNA DLGAP1-AS2 promotes the radioresistance of rectal cancer stem cells by upregulating CD151 expression via E2F1

Sheng-Ying Xiao,Zhi-Guang Yan,Xiao-Dong Zhu,Jun Qiu,Yi-Chen Lu,Fu-Ren Zeng

Translational Oncology（2022）

Cited 7|Views5
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Abstract
•DLGAP1-AS2 knockdown inhibits radioresistance of rectal cancer stem cells.•DLGAP1-AS2 elevates CD151 expression via interactions with E2F1.•DLGAP1-AS2 facilitates radioresistance of rectal cancer by interacting with E2F1 to upregulate CD151 expression.•DLGAP1-AS2 promotes radioresistance of rectal cancer via modulating E2F1 to elevate CD151 expression through activating AKT/mTOR/cyclinD1 signaling.
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Radiation resistance,Rectal cancer stem cells,LncRNA DLGAP1-AS2,E2F1,CD151,AKT/mTOR/cyclinD1 pathway
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