Effect of Glucocorticoid and 11-Hydroxysteroid-Dehydrogenase Type 1 (11-HSD1) in Neurological and Psychiatric Disorders
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY(2022)
Abstract
11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) activity is implicated as a moderator of the progression of multiple diseases and disorders in medicine and is actively subject to investigation as a therapeutic target. Here we summarize the mechanisms of the enzyme and detail the novel agents under investigation. Such agents modulate peripheral cortisol and cortisone levels in hypertension, type 2 diabetes, metabolic disorders, and Alzheimer's disease models, but there is mixed evidence for transduction into symptom management. There is inchoate evidence that 11 beta-HSD1 modulators may be useful pharmacotherapies for clinical improvement in psychiatry and neurology; however, more research is required.
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Key words
11 beta-HSD1 inhibitors,clinical translation,glucocorticoids,neurological,psychiatric
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